FGFR3 correlates significantly with tumour grade, stage and with a bilharzial infestation.
FGFR3 gene amplification was reported mainly in low grade and NNMBIC tumours.
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There is now compelling evidence that epigenetic modifications link adult disease susceptibility to environmental exposures during specific life stages, including pre-pubertal development.
Fibroblast Growth Factor Receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice. FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder. FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. Cell adaptation to activated FGFR3 includes Sprouty4 up regulation to inhibit the receptor-mediated ERKs activation from the endoplasmic reticulum. The Fibroblast Growth Factor Receptor 3 (FGFR3) Mutation Is a Strong Indicator of Superficial Bladder Cancer with Low Recurrence Rate. Pathology and genetics of tumors of the urinary system and male genital organs. PMCid: PMC1618623 AJCC CANCER STAGING MANUAL Seventh Edition American Joint Committee on Cancer Executive Office, 633 North Saint Clair Street Chicago, IL 60611-3211, 203-504. Fibroblast Growth Factor Receptor 3 Mutations in Bladder Tumors Correlate with Low Frequency of Chromosome Alterations. Connexin 43 expression predicts poor progression-free survival in patients with non-muscle invasive urothelial bladder cancer.
Data concerning age, sex, tumour grade, stage, and associated bilharziasis were obtained.
Each case was studied for FGFR3 expression, and FISH technique was applied on forty malignant cases that show high protein expression.
CONCLUSIONS: FGFR3 overexpression in malignant cases was significantly higher than in chronic cystitis.
FGFR3 gene amplification was reported mainly in low grade and NNMBIC tumours. https://doi.org/10.1097/00001648-200111000-00022 PMid:11679802 Pritchett TR, Wang JK, and Jones PA.
RESULTS: The highest incidence of cystitis was in the fourth decade while of bladder cancer was in the seventh decade.